Jan 8, 2026

EPA approves Biotalys biofungicide for US growers

Biotalys has received U.S. Environmental Protection Agency approval for EVOCA, its first biofungicide, marking the company’s initial U.S. regulatory clearance for a protein-based fungicide.

EVOCA targets botrytis, commonly known as gray mold, and powdery mildew in high-value fruits and vegetables. The product introduces a new mode of action aimed at managing resistance and is designed for use in both greenhouse and outdoor production systems. According to the company, the biofungicide can be applied pre- and post-harvest and integrated into existing crop protection programs.

With federal approval secured, Biotalys plans to proceed with state registration reviews, including California and Florida, two major production regions for fruit and vegetable growers. In Europe, EVOCA has entered the peer review process, with the Netherlands proposing approval pending additional data requests.

The EPA also issued a final rule in late October 2025 exempting EVOCA’s active ingredient residues from tolerance requirements, meaning no maximum residue limits will apply to treated crops.

“This approval marks a major regulatory milestone for EVOCA and moves us closer to delivering a new, sustainable tool for farmers to protect their crops,” said Kevin Helash, ceo of Biotalys.

Biotalys is also preparing regulatory submissions for EVOCA NG, a next-generation formulation using the same active ingredient. The company expects U.S. registration for EVOCA NG in 2028–29.